This report studies the conceptual framework and connotative characteristics of the people’s quality of life in the new era，and uses the fuzzy comprehensive evaluation method based on AHP to evaluate the high quality development of the people’s life in the western region of the 2010-2016 years，and further analyses the time series and regional differences. It is found that the quality of life of the western region has been greatly improved since 2010，especially since 2012. The improvement of living standard and living facilities is higher than that of living environment and living conditions. However，there is a big gap between the provinces in the western region in terms of quality of life. The difference of economic development level is the key factor affecting the difference of quality of life. Therefore，improving the living environment and living conditions and narrowing the gap of regional development is the policy implication of this research conclusion.