With the rapid development of mobile Internet，Internet access devices of Internet users are concentrating on mobile terminals. WeChat has become an important information access port for mobile terminals，providing a new direction and possibility for interpersonal communication. As one of the windows of new media，WeChat public account is mainly based on mass sending and interaction of messages. It has received more and more attention from the general public. Access to information has become the primary objective of users' attention to public numbers. Using Tencent science and technology，Sharp science and technology，innovation and entrepreneurship Zhong Guan Cun We Chat public channel and Shanghai science and technology as the reference，this paper searches for the interesting points of hot articles and deeply analyzes the factors that affect the public attention and influence of WeChat public channel to provide suggestions of effective operation of National Science and Technology Innovation Center public number.