In the new era under the new situation，with the deepening of the Belt and Road，small and medium-sized enterprises（SMEs）are facing unprecedented broad opportunity and playing more important role in this process. Compared with large enterprises，SMEs has the comparative advantage，such as innovation and management efficiency. When integrated into the Belt and Road，especially in the way along the market to go out，SMEs show some typical models which has some reference value for the other. Last，as for some challenges and problems SMEs faced，some countermeasures and suggestions are put forward.