The social cognitive theory indicates that meta-stereotype affects intergroup relations widely and meta-stereotype threat has a destructive effect on intergroup relations. In addition，intergroup anxiety plays an important mediating role between meta-stereotype threat and intergroup relations. Thus，this paper explores the internal mechanism between meta-stereotype manipulation and doctor-patient relationship by means of the experimental method. Forty-seven doctors and fifty-eight patients were randomly assigned to a meta-stereotype threat（MST）group and a non-MST group. The results indicate：（1）The intergroup anxiety under the meta-stereotype threat（MST）condition was higher than the case of non-MST condition，doctor-patient relationship of MST condition was worse than the case of non-MST condition，the doctor-patient relationship among doctors was worse than the patients’.（2）Intergroup anxiety entirely mediates the effects of meta-stereotype on doctor-patient relationship.