This chapter explores the model of innovation and entrepreneurship in China through detailed cases and data from various regions of the country，and summarizes the trend of in “mass entrepreneurship and innovation” hot industries such as education，healthcare，new energy and new material，finally it will provide reasonable suggestions for promoting the further development of China’s “mass entrepreneurship and innovation.” For the innovation，this report analyzes several classic models such as the global resource allocation of large enterprises，Integration of production，learning and research and new research institutions. For the entrepreneurship，this chapter focuses on important models such as fission enterprise model，the entrepreneurial model of Chuang Ke，and the model of public financing.