In the big data time，data present the trend of explosive growth and mass aggregation，and the mankind's ability to accumulate data is far higher than the ability to analyze and process data. Data congestion，distortion，security and other problems come one after another，which has aggravated the uncertainty and unpredictability of the society and prevented mankind from perceiving and transforming the world. To this end，this report，based on the application practices of complex theory and block data theory，innovatively proposes the theoretical and practical system for activation data science，and systematically explores its theoretical foundation，principle of operation and application model. The activation data science is the mass data storage，processing and utilization solution that fully exerts the human-machine mass intelligence as the core and combines data science，life science，social science，intelligence science and other disciplines. The appearance of activation data science is of great theoretical and realistic significance to solve the trouble of mass data，eliminate perspective barriers and terminate future data congestion.