World merchandise trade experienced its lowest growth rate in 2016 since the financial crisis of 2008. Meanwhile，the economic cooperation between China and ASEAN is also facing a dilemma of insufficient motivation. The total volume of trade in goods within this region has declined for two consecutive years and been imbalance for several years. The relatively backward level of infrastructure in ASEAN has limited the relocation of regional industrial chain. However，the construction of 21st-Century Maritime Silk Road offers new opportunities and impetus for China-ASEAN cooperation in the following decade. Future cooperation under the frameworks of the 21st-Century Maritime Silk Road should be integrated with the construction of China-ASEAN community of shared destiny. It is also essential to forge a new model of regional cooperation between China and ASEAN. Through these efforts，it’s likely to achieve a balanced bilateral trade and investment activities，and make ASEAN a positive example as a prior and vital area of construction.