Since 2002，“Opening of Gambling Right” with the “Mainland self-guided walking tours”policy implementation，the gambling industry-led Macao economy has made an unprecedented development.However，the past two years，by a variety of unfavorable factors，the income of Macao gambling industry continued to decline. Based on the theory of system dynamics，this paper analyzes the investment situation and industrial structure of gambling enterprises in Macao.Through the establishment of a complete system dynamics model，explores the investment strategies which can maintain the healthy and sustainable development of the overall economy of Macao based on the perspective of industrial diversification and then make relevant policy recommendations.