With the continuous deepening of human awareness of disease，evidence-based medicine has become an important part of the medical decision-making system. In recent years，considerable clinical research has been made，especially the high quality evidence based on Chinese population. Imaging，stem cell reprogramming，cancer early diagnosis and other new technologies has further transform to clinical application. These evidence provides theoretical support for health management. The practice of numbers of national key project of drug research and development，precision medicine research and major chronic non communicable disease prevention will leading China’s clinical research to new heights；The development of medical big data，new mobile medical technology services have formed a new form of medical science and technology Service. The traditional sense of the basic research，clinical research，and technology industrialization has become blurred，and provided strong support for the health management and the related industries.