The industrial transformation and upgrading refers to a high degree of industrial structure，high added value at the industrial level and green development of the industry. As the most concentrated industrial development zone in the country，the industrial transformation and upgrading of the Yangtze River Economic Belt are the main battlefields of economic supply-side structural reform. It is also the basis and result of enhancing regional economic competitiveness and the technical，product and material basis of regional green development. In recent years，as a whole，the industrial output continues to grow，industrial structure continues to optimize，environmental loads continues to decrease. However，from a horizontal perspective，the results of industrial transformation and upgrading in the Yangtze River Economic Belt are extremely uneven. Shanghai，as a benchmark，leads the industrial transformation and upgrading of the Yangtze River Economic Belt. To realize the abutment，Shanghai needs to further enhance the functions and levels of global city，enhance its ability to allocate resources globally，give full play to its transnational hub for industrial resource allocation，its central coordination in industrial development，its central motivation in industrial innovation networks，and its conduction of industrial green development for the Yangtze River Economic Belt.