Based on the basic principle of logo therapy，the characteristics of physical and mental development of adolescents and the initial assessment of the main body of the case，the author puts forward seven ways to seeking meaning of life：important people in life，reviewing pleasant events in the past，experiencing the satisfaction and happiness immediately，seeking previous hobbies，tapping the self strength in the suffering of the disease，paying attention to the power of example. Based on those seven ways，The author designed intervention plan to help the teenagers suffering from bone tumor. Studies have shown that the owners’ meaning of life scores have greatly improved，the treatment of case is valid. Finally，the author puts forward a practical model of case work for cancer patients in hospitalized teenagers. The author emphasizes that for the teenagers suffering from bone tumors，they pay more attention to the experience of current life and the yearning of life rather than review the course of life.