The economy of Guangdong is obviously opening-oriented；Innovation has the characteristics of open innovation. It is the inevitable requirement of regional development to promote scientific and technological innovation. Innovation is necessary，which can promote the activity subjects reasonable using and allocating innovation resources. Innovation of international integration makes a greater contribution to the economic growth stably. On the basis of literature review，the results of analyzing data to describe the open innovation of Guangdong province，which can judge the current stage of open innovation. Study on the existing problems and reasons to encourage innovation in. Guangdong province. Learning from successful models to make in-time reviews and propose new measures.