Nowadays，With the deepening of medical and health system reform in China，the medical disputes are rising frequently and malignantly，which provoking the doctor-patient relationship to be increasingly tense. The direct cause of the doctor-patient relationship’s tension is the doctor-patient mutual distrust. Therefore，to effectively alleviate or eliminate the doctor-patient relationship’s tension，we must construct the doctor-patient mutual trust. However，to construct the doctor-patient mutual trust successfully，we must make full use of local resources. The Guanxi operation which is presented in “seeing a doctor by entrusting the acquaintance” or “seeing a doctor by seeking the Guanxi” in China implicates “The strange relationship’s familiarization” which is the local construction mechanism of the doctor-patient mutual trust with Chinese characteristics. “The strange relationship’s familiarization” can be used as an effective social mechanism to construct the doctor-patient mutual trust after its basis is undergone the appropriate “creative transformation”.