Negotiation is the main foundation of resource exchange between doctors and patients. During the process，patients offer money or spiritual resource，they are likely to negotiate the quality and quantity of medical service or knowledge from doctors. Negotiated agreements drive parties to abide by certain rules of exchange and allow for individuals to be trusting of one another. However，because life as the main resource exchanged is so important for parties，simplified negotiation by the medical system take more risk of evolving distrust or breaking down trust，while exchange process incite inequality that making individuals suffer loss of life，even if parties realized they are responsible for the carelessness of negotiation rules. In addition，reciprocal exchange plays auxiliary function to catalyze the evolution of trust and normalize the behaviors of doctors and patients through exchanging a kind of resource named Renqing.