As a threat to public health，depression does not only harm to personal health，but also is a serious obstacle to the society development.Over the past decades，social networks and social media have largely impact the way people communicate and interact with each other and changed the way people search and receive information.In addition to the traditional mainstream media，social media has become an important channel for depression building and spreading.However，the information on social media is mostly disorganized，which has brought risks and hazard to the health communication of depression.Therefore the research origins from the theoretical framework of health communication，exposes the information ecology and cause attribution of depression on social media，analysis the reasons for this situation and the possible improvement.Take Sina WeiBo as an example，summarizes all the information related to depression for the past 4 years on this platform，focused on the media bloggers，the top ten mainstream media，verified weibo users and health bloggers on depression.The study indicates that social media information about depression tend to take anecdotical frame，the attribution and recovery solution are more directed at individual rather than the society.Homogeneity tendency of reporting content and topic discussion is serious，social support of depression and the information popularization is not optimistic.There still need efforts to help spreading the health communication of depression.