According to the standard of world health organization，the health status of Shenzhen's residents has reached the leading domestic level. In 2015，the health knowledge，health behavior and health skill literacy level of Shenzhen's residents are 23.51%，18.89% and 8.28% respectively. The health literacy level of registered population is higher than that of non-registered population，；the health literacy level of females is higher than that of males；the health literacy level of young labors is higher than that of older labors；the higher the residents' educational level and income per month is，the higher the health literacy is. According to mortality，top three diseases are Malignant tumor，heart disease and cerebrovascular disease. Shenzhen's residents consider that social and environmental factor，behavioral and life style，healthy services and inherent cause are the health factors in order. Health management and investment would protect the residents' health. According to the health status and risk factors of the residents，it is proposed that the risk factors should be restrained and the health status should be improved. It is suggested to build a healthy environment and a healthy society，to strengthen health management and cultivate healthy population，to carry out health services and guide healthy consumption，to perfect the guarantee mechanism and realize the health equality.