Heat waves，storms，coastal floods，typhoons，drought and other weather and climate-related disasters occurred frequently along the Belt and Road region，under the background of global warming，with complex and diverse climate types. The climate risks in major countries along the Belt and Road region are generally high，countries in South Asia and Southeast Asia most affected. Projection results from the Coupled Model Intercomparsion Project show that the frequency and intensity of future extreme climate events along the Belt and Road region will further increase. In order to actively respond to the possible impact of changes in climate and extreme weather and climate events on the human and natural systems along the Belt and Road region，scientifically manage the climate disaster risks faced by most countries，enhance the comprehensive capacity to adapt to climate change and disaster prevention and mitigation，several response solutions are given at the end，to provide scientific and technical support information for the international cooperative actions along the Belt and Road region and the achievement of regional sustainable development.