Central Asia and Transcaucasia，located in the core area of Eurasia，with an abundance of oil and gas resources，are of great strategic importance.In recent years，however，the rampant Three Evil Forces has resulted in great regional instability.The informatization development has been hindered by the economic underdevelopment and social instability.By the analysis on the Information Society Index（ISI）of the countries in this region，this paper reaches an agreement that the overall informatization development of this region is at a considerably low level，except for Kazakhstan，which has a positive situation of informatization development，while the informatization development level of the rest is under the world average，and under the Belt and Road countries' average as well.This paper has made a detailed study of the informatization development of the countries with representative significance such as Kazakhstan of Middle Asia and Azerbaijan of Transcaucasia.With great importance attached to information technology developing，Kazakhstan has promulgated successively some strategies on national informatization such as Informational Kazakhstan 2020 and Digital Kazakhstan Planning，and has invested a considerable amount of money，greatly facilitating the informatization development，while the informatization development of other Central Asian countries is constraint by either the underdeveloped economy or the unstable political situation.Countries and regions of Transcaucasia all have a very similar degree of informatization development，ranking around the global 70th.Nevertheless，there is a highlight in cross-regional information infrastructure construction：the Trans-Eurasia Information Superhighway Program proposed by Azerbaijan，which has attracted many other countries to actively participate in.Currently，the information cooperation between China and those two regions is very limited，but since The Belt and Road Initiative has been brought out，there arises an urgent need for China to improve its resources of westward international communications network facilities，communication capability and service level，and China is keeping strengthening the information cooperation with those regions，especially in the field of network infrastructure construction.