Making sure the Poverty Alleviation and Prosperity Project completed on schedule，is the basic guarantee to finish building a moderately prosperous society at the end of 13th five-year. Base on the location，thoughts and aim of poverty alleviation and development during the period of 13th five-year，this paper point out the key point and difficulty of Poverty Alleviation and Prosperity Project，and put forward the corresponding countermeasures and suggestions.