The weakness of Jiangsu economy endogenous dynamic are such as frontier technology cooperation，introduction of top talent，undertaking major national science and technology projects，innovation ecosystem construction，innovation and brand building of large enterprises，etc. In the first time we should create innovative eco collaborative system around the high-end talents，in order to gather first-class talents，allocate talents efficiently，undertake major projects，and improve innovation effectiveness. Secondly we should encourage entrepreneurs to enhance innovation ability，improve product quality，build brand，and exploit new market much more aggressively than before. In the end we should utilize rationally the supporting and leading role of national strategies，in order to promote complementary advantages among different regions and different departments，expand the basic of economic endogenous growth，and form a more effective endogenous development mechanism.