Multicultural experience is a double-edged sword. It may enhance the integrative reactions among open-minded individuals，but it can also evoke exclusionary reactions toward foreign cultures. 91 Chinese undergraduates with few or relatively extensive multicultural experience evaluated a print ad of McDonald’s plan to open a shop at the Great Wall. Among those who have less extensive multicultural experience，openness was not related with their attitude toward the McDonald’s. Among those who have more extensive multicultural experience，openness was associated with a higher level of negative attitude to the McDonald’s. The interactive effects of multicultural experience and openness were more likely to occur for individuals who identified more strongly with Chinese culture. Qualitative analysis based on in-depth interviews with participants showed that the exclusionary reactions toward McDonald’s arose from effortful instead of reflexive cognition. These results challenge the current in culture-mixing studies that integrative reactions result from effortful information processing and exclusionary reactions from reflexive information processing.