In order to build national center city and international trade center, Guangzhou has to speed up on enterprises' "going out", take full advantage of overseas markets and resources, nurture and form a range of local multinational enterprises with proprietary brand and intellectual property.This study analyzes the current status of Guangzhou enterprises' going international, elaborates the opportunities and challenges these enterprises face, explores into experience of domestic and oversea cities, and puts forward feasible strategies for Guangzhou to nurture local multinational enterprises. <<