In this paper, the present situation of doctor-patient contradiction and dispute mediation in guizhou, carried on the thorough research on the basis of analyse the cause and the doctor-patient contradiction mediation difficulties, suggested that party committees and governments focus on increasing financial investment, further deepening the reform of medical and health institutions and mechanisms, vigorously strengthen medical personnel professional and technical skills, services, training and legal sense, and in minimizing the doctor-patient contradiction happened at the same time, strive to build more consummate the doctor-patient contradiction mediation mechanism in accordance with the law.