In recent years, the number of HIV/AIDS infections and deaths in guizhou province has been increasing, which is one of the 13 "one" provinces in the country. For insight into the reality of children affected by HIV/AIDS in guizhou social welfare, to establish and perfect the guizhou province affected by HIV/AIDS, child welfare security system in guizhou province home office, adopting children in guizhou, and organization of the welfare centre, set up the "guizhou province affected by HIV/AIDS children welfare" research group, four group organized by guizhou university of finance and economics experts into downtown guiyang, zhunyi, liupanshui city, including, anshun city, kaili city, bijie city and other cities and counties has carried on the empirical research. In guizhou province were analyzed deeply affected by HIV/AIDS children's welfare and its implementation present situation, existing problems and reasons, in combination with the practical situation of investigation and analysis, and guizhou province, put forward the perfect guizhou province affected by HIV/AIDS child welfare policy Suggestions.