The innovation drive is to realize the transformation of development and the revitalization of northeast old industrial base of the strong support and the important strategic choice.To implement the strategy of revitalization of the northeast, from the accumulation of science and technology education resources, industrial foundation and future strategic national policy support, etc., the micro foundation for the construction of innovation driven development laid a good.By the low degree of marketization, high degree of economic risk accumulation, integration innovation relative lack in funding, technology and economic development, regional cooperation is not perfect enough, such as changes in the institutional obstacles and development environment, innovation-driven development momentum is still inadequate.Needs in the development of the old industrial base transformation strengthening innovation drive, promote the development of manufacturing to high-end, promote the development of science and technology and economic integration, optimize the environment of enterprise innovation and development, the formation of the culture atmosphere of enterprise innovation and development.