What is TCM lack of？Lack of history？Lack of culture？Lack of means？It’s lack of evidence，data and information！In the past，scientific research did answer to “why” and “what”. The information age requires us to first answer “can or cannot”，first to understand the relationship in-between and then to find the mechanism，to find the cause and effect. Information technology is the support of scientific and technological progress of TCM. With scientific theoretical way of thinking based on information - energy - substance，with research methods of Systematic biology analysis technology，TCM intelligent technology，digital body holographic technology，we should do it well digitalization of ancient literature，TCM knowledge library，and digitalize resources protection of famous and experienced TCM doctors.