Nowadays，It has already been ten years for the medical service opening-up in Chinese mainland to HK and Macao capital market. However，the medical institutions of HK or Macao have not formed a group of influential medical power，still been groping ahead. Through the investigation of the Medical Service openness status in Guangdong Province under the Framework of CEPA，this paper analyzes the characteristics of regional distribution，type of organization，service targets and operational performance of these medical institutions，and their plights during the period of operation. Furthermore，this paper explores the differences and conflicts between HK and Chinese mainland medical management system，and put forwards policy suggestion to further promote the openness of medical services industry.