This paper utilizes seven provinces nationwide rice production data by propensity score matching method（Propensity Score Matching，PSM），excluding the self-selection problem of endogenous influence，to evaluate the difference in species and quantity of pesticides application between Regional Pest Control and dispersed insect control by farmers. That is to say，whether this professional plant protection has achieved good environmental benefits and provided safe food for people？The research conclusions can provide the reference for implementation of Regional Pest Control program from the perspective of the supply of safe food. The research results show that the use quantity of the pesticide has been reduced significantly through implementation of Regional Pest Control program，improved the application of environmental-friendly pesticides and there are significant differences in pesticide application between small-scale growers and large-scale growers who have adopted the program. It is therefore recommended to improve the program’s financial support，strengthen epidemic forecasting，improve control effect and improve the program’s coverage. Furthermore，the authority should strengthen the guidance and training of professional pest control，encourage farmland transfer and promote agricultural production scale operation.