NPOs are major parts of social system and are of vital importance to the development of social innovation. This paper summaries four kinds of NPOs and discusses their process of development and strategies from the perspective of life cycle by multi-cases method. After field researches into different NPOs’ life cycles，the paper draw the following conclusions：1） NPOs can cycle their lives by metamorphosing；2） the balance of NPOs’ mission，ability and support is the basic of building to last，which can promote social government and increase well-being. The paper suggests that actions should be made to strengthen the engagement of social innovation，release NPOs’ vitality，improve the social-government relationship and build innovative mechanisms.