Objective To provide the data basis with helping the government decision-making to establish an available mechanism for effective response to HIV in post-disaster settings. Methods An open-ended interview schedule with a non-matched qualitative data collection method to interview local informants，governors and vulnerable population affected by HIV in 9 earthquake disaster counties of Sichuan，PRC. Results The work base as a unformatted pattern in grassroots level was exists for response to HIV in emergency settings. Conclusion Building an available mechanism for effective response to HIV and other emerging infectious disease（EID）in emergency settings through timely review key steps with a whole insight to support the extension of community-based response to disaster as a significant approach is highlighted in the study.