Okinawa base issue is one of the most difficult issues both in Japanese domestic politics as well as Japan-U.S. relations. In 2015，the relocation of Futenma base becomes the focus of the Okinawa base problem，which has undergone the stages of inspection，negotiation，cancellation of permission and all-out confrontation. The opposition between the central government and Okinawa has became intensified，with the issue having been through a series of twists and turns and constantly fermented since the end of 2014 when Takeshi Onaga took office as Governor of Okinawa. The issue of Futenma base’s relocation is very complicated under the joint impact of Japan-U.S. military alliance，American strategy in Asia-pacific region and the political struggle and gaming among Okinawa，Japan and U.S.，and it will continue to impose important impact on domestic politics in Japan，Japan-U.S. military alliance and U.S regional strategy.