The Urban Agglomeration in the Middle Reaches of the Yangtze River mainly Contains Wuhan Wangjiadun CBD，Changsha Furong CBD and Nanchang Honggutan CBD. These CBDs are at different stages of development. We analyzed the basic situation of the three CBDs in the Urban Agglomeration，from the aspects of headquarters economy，building economy，industrial development and other aspects of its contact with the regional economy，and we further analyzed the challenges they faced such as management mechanisms，human resources and other issues. At last We proposed to build characteristic CBDs，improve the management system，strengthen human resources for leading to a sustainable development of the Urban Agglomeration in the Middle Reaches of the Yangtze River and the wider central region. <<