Yangtze River Delta is one of the most economically developed regions in eastern China，and it is one of the most seriously polluted areas with high energy consumption and dense air pollutant emissions. It is faced with high environmental pressure due to the industrial chain and dense transportation network. Joint prevention and control mechanism was established in January 2014 in order to resolve the heavy air pollution，and it has pushed forward significant regional air pollution control progress. Although the mechanism has accomplished remarkable achievements，there are still some key bottlenecks related to mechanisms，policies and supervision. Based on analysis of the regional air pollution issues，achievements and shortcomings，and survey of the joint air pollution control experiences both at home and abroad，some suggestions which may improve the mechanism are proposed in this article.