It is difficult to solve all environmental issues of Yangtze River locally. In this study，the necessity of establishment of the coordination mechanism in the region will be discussed based on the deepened analysis of surface water resources，water quality and pollution characteristics in Yangtze River Delta region. It is suggested that we should further promote regional cooperation，improve the cooperation mechanism，continuously enhance the level and depth of the cooperation，further unify the water environmental planning and standard，improve information sharing，to achieve the sustainable development of the region.