The emergence and continuous iteration of we-media trigger a tide of media practitioners’ resignation. There are the largest resignation tide and start-up tide with the emergence of We-chat. Resigned media practitioners who growing up in the traditional media continue to engage in media production activities in more personalized way after leaving the system and more influential we-medium are mostly created by them. The analysis of resigned media practitioners’ We-media start-up helps better understanding of the dynamic relationship between we-media and traditional media and the operating mechanism of the entire media ecology. This paper selects nine we-medium to analyze resigned media practitioners’ We-media start-up in the past three years，including resignation reasons of this group of media practitioners，start-up drive，start-up situation and the interaction between we-media they created and the media ecology.