Since the new century，creative industry has become a new engine for the city development with the wave of globalization and the rapid development of knowledge economy to promote the economic，cultural and social transformation. Creative economy and Urban economy interacts each other，creative space and urban space promotes each other. Creative industry park evolution relevants to the transformation of urban spatial structure；how to optimize the transformation of urban space with the help of creative industry park evolution and how to use urban spatial reconstruction to promote the development of creative industry have become hot spots in academic. Shenzhen is the first city in China that awarded the title of “the capital of design”. The creative industry develops rapidly，the spatial agglomeration of creative industry parks becomes more and more obvious. In this paper，from the breakthrough point of the evolutionary economic geography theory，deeply discusses the interactive relationship between creative industry park evolution and the transformation of urban spatial structure. First of all，this paper describes the current development situation of creative industry in Shenzhen in terms of its development scale，the degree of concentration and environment，qualitatively analyzes the spatial evolution procession of creative industry parks；then with further analysis of the maps，it summarizes the features of space distribution，concludes models of creative industry parks’ spatial expansion and organizational models；finally，it qualitatively analyzes the relationship between Shenzhen creative industry park evolution and the urban spatial reconstruction from the view of economic，social，cultural and transportation and offers some suggestions to promote the development of creative industry clusters.