The municipal development of Beijing has come to a bottle neck and a historic juncture with highly frequent occurrences of urban diseases. From the perspective of the transformation of social governance and the transformation of civilization，the cure and treatment of urban diseases，especially the diseases of the mega-city，should focuses on two dimensions—the government administration and the behavior of the people. The government plays a critical role as a leading entity in the process of overcoming urban diseases. The behavior of the people includes direct participation in the governance，such as put forth proposals on treatment of urban diseases，and cooperate in the implementation of relevant governance initiatives. The indirect participation of the people，including monitoring the government in its implementation of administrative policies and promoting civilized life styles in daily life，constitutes a more fundamental aspect in overcoming urban diseases and elevating urban civilization.