The development of creative industries benefits a lot from high-tech, which can preferably express the creative ideas and sometimes leads to the innovation of cultural lifestyle. Therefore, to promote the integration of culture and technology and to improve the technology equipment in cultural enterprises can be of positive value to enhance the quality of creative industries. On the base of the features of animation industry and the successful experience in USA and Japan, this paper mainly explores the paths to optimize the development of Chinese animation industry through the promotion of the integration of culture and technology. It indicates that the development of animation industry requires the integration of culture and technology in all aspects of the industry chain. Although the role of market and government are different in the USA and Japan, the development of animation industries in this two countries all depend on the deep integration of culture and technology. The main characteristics of the integration mechanism are as follows, taking the market as guidance, the interest coordinating mechanism as safeguard, the construction of cooperation platform as carrier and the cultivation of human capital as support. In recent years the animation industry has also achieved rapid progress in China, but its creative level and profitability are still low, which may be related to the limited integration of culture and technology. This paper also puts forward some recommendations in the end. <<