Beijing-Tianjin-Hebei cross-regional science and technology cooperative innovation is an important part and basis of Beijing-Tianjin-Hebei cross-regional development strategy. The mechanism of Beijing-Tianjin-Hebei cross-regional science and technology cooperative innovation need to build a mechanism system to coordinate the relationship between the interaction of each subsystem. It can be set up from dynamic mechanism，implementation mechanism and assessment mechanism. Through the three sub-mechanism combination，it will promote the development of Beijing-Tianjin-Hebei Cross-regional science and technology cooperative innovation.