Talents are the source of vitality for the Central Business District （CBD）. Given that talents are the most critical resources to the CBD’s innovation and its economic development，this chapter focuses on analysis the successful experiences and effective practices in attracting the high-end talents in the case of Manhattan，Shinjuku，Hong Kong and some other world-wide top CBDs. This chapter creatively classifies the talent resource into three types：leading，support and management coordination，by taking Beijing CBD as an example. A large number of data were analyzed to figure out the factors influencing the CBD talent aggregation，as well as ranks the importance of these factors according to three aspects — the industry environment，social environment and talent environment. In the end of this chapter，some specific measures and policies are presented to perform a certain guiding significance in the talent resource development of Chinese CBDs.