Human resources is the core element of the modern economy，but also a source of innovation and development capabilities for a region. Although the central region has abundant labor resources，but the situation of its human resources is not optimistic，there are generally some problems in six provinces of the central region，such as the limited human resources pool，the lower human resources quality，the serious brain drain，and the lower technical conversion rate and so on. The reason is that the institutions and mechanisms of human resources is relatively backward，and it is not conducive to the training and development of talents. Restricted by the economic and social conditions，the investment to human resources is insufficient in the central region，and its policy guidance and training work is not enough，too. The difficulties focuse on：human resources outside is difficult to be brought in for the lack of attraction，human resources inside is difficult to be retained for the lack of cohesion，existing human resources is difficult to be used for the lack of driving force. These problems exist in all areas and departments，and have dragged down the rapid progress of various undertakings. To this end，the central region should follow the law and rules of using human resources，innovate the institutions and mechanisms，and focus on the high-level and highly skilled personnel，coordinate the development of all types of personnel，and thus help “the rise of central region” strategy to be implemented successfully.