This paper focuses on the comprehensive review of the current situation and problems of the drug safety and social participation which based on the four aspects of community management,industry management,public participation,and media involvement.The author discussed the practice of the FDA(Food and Drug Administration,USA),Center for Sciences in the Public Interest (CSPI),and other institutions.Based on the empirical research the paper analyzed the social management method of drug safety administration,which appears the social participation status and characteristics of the recent social participation about the drug safety administration comprehensively.The paper proposed the Mechanisms and forms social participation about the drug safety,which it is an important reference to strengthen and innovate social management of drug safety. <<