Based on the comparative analysis between the Marketing Authorization Holder （MAH） system of developed countries and Chinese binding management mode of MAH and Production License Holder，the author discussed the advantage of MAH system to be established. If MAH system was established in China，it would promote the enhancing of administration，defining of company legal behavior，marketing developing of the technology transferring，specializing deeply of division of labor and the good resource allocation. Based on the above mentioned，the author suggested that Chinese drug administration should establish the related regulations，such as admittance MAH system，applying program of separating between production and marketing，enforcing insurance system，making MAH being the leading of the production and marketing，building the regulations of MAH system，and so on.