The Realization pathway to build Guangzhou as a harmonious city integrated with Human and nature as a complex system project，involves every aspect of urban construction.This paper expounds the realization pathway to build Guangzhou as a harmonious city integrated with human and nature from the aspects of building resource-economized and environment friendly industry system；keeping the natural ecology capacity of ecology system；leading the healthy developed urban construction system；enhancing the resource system of utilized efficiently and accelerating the environment system in improving environment quality.