Comprehensively using the methods of ESDA，Moran’s I，Getis-Ord General G and spatial variogram，this article describes and analyzes the spatial characteristics of per km2GDP in China during 2000-2010.（1）per km2GDP increases from 103×10⁴yuan/km2 in 2000 to 418×10⁴yuan/km2 in 2010. Rapid economic growth of China experienced a spatial shift from coastal regions to inland regions，and economic gravity center moved northward and westward.（2）Considering the overall spatial framework，per km2GDP at county level in China shows a significantly trend of spatial natural correlation. The hotspot regions expand obviously，with circular space structure centered on the area along Bohai Rim，the Yangtze River Delta and the Zhujiang Delta.（3）The spatial self-organized characteristicsof per km2GDP has become stronger and stronger. The homogeneousness of per km2GDP in the direction of northeast-southwest is typical for its relatively small spatial difference.