It’s the prominent feature of the development mature in Urban Agglomeration that build the inter city cooperation mechanism，and to definition the comparative advantages of urban industrial is the main problems in promote the cooperation between the industrial division. Measurement and analysis the industrial comparative advantage in Wuhan urban agglomeration basis on use the principal component analysis to recognition and measurement the dominant industries in Hubei Province，and Put forward policy recommendations on the city industrial position and direction of development cooperation division of labor between urban in Wuhan urban agglomeration.