IP-based operation is a typical mode of operation in the cultural entertainment market in recent years. As museum cultural resources have received public attention，the emerging ecological model of IP-based operation has gradually extended to the field of heritage and museums. The sectors of Henan heritage and museums have seized the opportunity to promote cultural creativity and transboundary cooperation，and have been rewarded with certain achievements ever since. However，on the whole，the development and operation of IP on museums in Henan Province are still in the early phases of exploration，with development among museums unbalanced，continual innovation insufficient and industrial ecology unsound. Therefore，it is necessary to deeply excavate the connotation of museum cultural relic’s resources and create a unique content system. It is necessary to construct industrial ecology to extend brand value，and diversify channels of dissemination to improve communication effect. Various measures should be tried and taken to improve the IP operation level of museums so as to further promote the development of cultural industry in Henan Province.