This report evaluates the performance of collaborative innovation network in the Yangtze River Delta from 2015 to 2019 through entropy method，and analyzes the advantages and disadvantages of the development of urban collaborative innovation network in the Yangtze River Delta from three aspects of economic development level，geographical location and development trend. Focusing on the integration of the Yangtze River Delta，the report proposes that the construction of collaborative innovation network should be promoted by building the highland of collaborative innovation network development，optimizing the collaborative innovation environment，and strengthening the integration of innovation resources.