With the rise of a new round of scientific and technological revolution and industrial transformation，digital technology and real technology，digital economy and real economy show a trend of deepening integration，of which manufacturing is the most important industrial sector for digital and real integration. This paper proposes that the scope of digital and real integration of manufacturing industry includes all fields within enterprises，the whole cycle of the value chain and the whole ecology of the supply chain. In terms of form，it is manifested as element integration，technology integration，facility integration and product integration. The integration of digital and reality in the manufacturing industry is based on connection，data-core，supported by computing power，driven by algorithms，and plays an enabling role in the manufacturing industry by integrating multi-dimensional data，discovering potential knowledge，replacing human labor，coding industry knowledge，software-defined products，and innovative business models. In view of the constraints of manufacturing capacity，digital level，digital capability，data flow and other aspects faced by the integration of digital and real manufacturing in China，it is necessary to accelerate the construction of information infrastructure，promote digital technology innovation，promote the digital transformation of manufacturing enterprises，improve digital economy laws，regulations and policies，and strengthen international cooperation in the field of digital economy.