As a “public health emergency of international concern”，COVID-19 has had a profound impact on the national economy and the people’s livelihood. Information has the function of “eliminating uncertainty”，and news reports are the main channel for the public to obtain information. Doing a good job in news reporting and public opinion guidance is not only a major event in governance，national security and statehood，but also a necessary link and content in public opinion response to emergencies. This article focuses on the “Beijing epidemic” event in May 2022，and takes the official microblog of “people’s Daily” as the research object to conduct an empirical study on how media news reports affect public sentiment. The research finds that the news frame and the emotional tone of news reports are the significant factors that affect the public mood. Appropriate reporting strategies of new government media can help calm public sentiment and help prevent and control the epidemic.